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Copovidone (PVP VA64/Kovidone VA64)

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Copovidone (PVP VA64/Kovidone VA64)

Product Name: Copovidone

Chemical Description: Vinylpyrrolidone with Vinyl Acetate Copolymer, PVP/VA 64 Powder

INCI/CTFA: VP/VA Copolymer

Pharmacopeia Name: Copovidone /Copovidonum

CAS NO.: 25086-89-9

Liveida ® Copovidone, an analog of povidone, is used as a tablet binder, a film-former, and as part of the matrix material in controlled-release formulations. In tableting, Copovidone can be used as a binder for direct compression and in wet granulation. Copovidone is often added to coating solutions as a film-forming agent. It provides good adhesion, elasticity, and hardness and can be used as a moisture barrier.

Liveida ® Copovidone has better plasticity than povidone when used as a tablet binder. It is less hygroscopic, more elastic, and better suited for film-forming applications than povidone. Copovidone is also used in cosmetics as a thickener, dispersant, lubricant, film-forming agent, and binder. It is widely used in the food, cosmetic, and pharmaceutical industries.

Liveida ® Copovidone is generally regarded as non-toxic. However, oral consumption of excessive quantities may cause stomach upset. It has not been shown to be skin sensitizing. Animal studies in rats and dogs do not show significant toxicity at high dietary levels.

Pharmaceutical Grade Specifications:

Appearance White to creamy white, free-flowing powder
Purity 99%
K Value 27 - 32.4
Aldehyde 500 ppm max.
Peroxide 400 ppm max.
Hydrazine 1 ppm max.
Monomers (Residue VP + Residue VA) 0.1% max.
Impurity A (2-Pyrrolidone) 0.5% max.
Heavy Metals 20 ppm max.
Loss on drying 5.0% max.
Sulphated Ash 0.1% max.
VA content 35.3 - 42% max.
Nitrogen 7.0 - 8.0 %

Cosmetic Grade Specification

Products Appearance K Value Solid % Residual Monomers of NVP % Residual Monomers of VA % Heavy Metal
Liveida®VA37E Solution 26 - 38 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA64 Powder 26 - 34 > 95% ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA64W Solution 26 - 34 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA64E Solution 26 - 34 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA73W Solution 26 - 34 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA73E Solution 26 - 38 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm
Liveida®VA55E Solution 26 - 38 49 - 51 ≤ 0.01 ≤ 0.01 ≤ 10 ppm

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