Liveida® Crospovidone/PVPP

1. Product Overview

Liveida® Crospovidone is a premium pharmaceutical excipient, a water-insoluble synthetic cross-linked homopolymer of N-vinyl-2-pyrrolidone. With its unique chemical structure and superior properties, it finds extensive applications in various fields, including pharmaceuticals, food, and cosmetics.

2. Basic Product Information

• Chemical Name: Cross-linked Polyvinylpyrrolidone, 1-Vinyl-2-pyrrolidone Homopolymer
• Pharmacopoeia Name: Crospovidone ,Crospovidonum
• INCI/CTFA ：Insoluble PVP
• CAS Number: 25249-54-1
• Molecular Formula: (C₆H₉NO)n
• Appearance: White or nearly white powder, odorless, and non-irritating.

3. Product Characteristics

• High Water Absorption and Swelling Capacity: It has a strong ability to absorb water and swell rapidly, enabling the quick disintegration of tablets and other formulations and enhancing drug dissolution rates.
• Excellent Complexation Ability: Sharing the same complexation capacity as Polyvinylpyrrolidone, it can complex with various substances, such as phenols and iodine. This property improves drug release rates, enhances bioavailability, and allows for the selective adsorption of polyphenols and complexation of endotoxins.
• Outstanding Stability: Insoluble in water, acids, alkalis, and common organic solvents, it maintains stable performance under diverse environmental conditions, ensuring the quality stability of formulations.
• Superior Fluidity: increasing the viscosity and improves the dispersion properties to reduce the sedimentation rate of drugs, meanwhile increasing the re-dispersibility of said sediment. Suitable for liquid and instant oral preparations.

4. Quality Control Standards

• Appearance Inspection: Rigorous checks ensure that the product is a white or off-white powder, odorless, and tasteless, meeting the appearance requirements of high-quality products.
• Identification Tests: Advanced identification methods are employed to ensure the authenticity and purity of the product.
• Acidity and Alkalinity: The pH value is controlled within the range of 5.0 - 8.0 (1% w/v water suspension), ensuring the product's stability and compatibility in different environments.

5. Product Applications

Pharmaceutical Field

• Tablet Disintegrant: Widely used in oral tablets, capsules, and orally disintegrating tablets, it serves as a super disintegrant, enabling rapid tablet disintegration in the body, accelerating drug release, and improving drug bioavailability. It plays a crucial role in formulations such as ibuprofen tablets and antibiotic preparations.
• Drug Carrier: It can adsorb components in drugs, such as enzymes and vitamins, improving drug stability and release characteristics, and facilitating the development of novel drug formulations.
• Clarifying Agent: In the production of traditional Chinese medicine and plant extracts, it effectively adsorbs impurities such as polyphenols and tannins, enhancing the clarity of the liquid medicine and ensuring the quality and safety of drugs.

Food and Beverage Industry

• Beer Clarification: Removes polyphenols and tannins from beer, preventing turbidity during storage, extending the beer's shelf life, and enhancing its quality and taste.
• Juice Clarification: Used in juice production to adsorb pigments and colloidal substances, making the juice clearer and improving its appearance quality and stability.

Cosmetics Industry

• Facial Masks and Skin Care Products: As an adsorbent or disintegrant in cleansing facial masks and skin care products, it can adsorb oil and dirt on the skin surface, helping to clean pores and leaving the skin feeling refreshed.

6. Product Specifications

Pharmaceutical Grade:

Product	Crospovidone Type A	Crospovidone Type B
Appearance	White or yellowish-white powder	White or yellowish-white powder
Identification	Meet ID Tests	Meet ID Tests
Solubility	Practically insoluble in water, in alcohol and in methylene chloride	Practically insoluble in water, in alcohol and in methylene chloride
Water-soluble substances	1.0% Max	1.0% Max
pH (1% in water)	5.0 - 8.0	5.0 - 8.0
Loss on Drying	5.0%Max	5.0%Max
SulphatedAsh	0.1%Max	0.1%Max
Nitrogen content	11.0-12.8%	11.0-12.8%
Impurity A	10ppm Max	10ppm Max
Peroxide(As H2O2)	400ppm Max	400ppm Max
Heavy Metal	10ppm Max	10ppm Max
Particle Size (μm), ≥80%	50-300	5-50

Food & Beverage Grade:

Product	PVPP( Single-use)	PVPP(Recycling)
Appearance	White to off-white,hygroscopic,free-flowing powder	White to off-white,hygroscopic,free-flowing powder
Nitrogen Content	11.0-12.8%	11.0-12.8%
Lead	2 ppm max.	2 ppm max.
Arsenic	3 ppm max.	3 ppm max.
Heavy Metals	10 ppm max.	10 ppm max.
pH(1% Suspension)	5.0-8.0	5.0-8.0
Residue on Ignition	0.4% max.	0.4% max.
Peroxides	400 ppm max.	400 ppm max.
N-Vinylpyrrolidone	10 ppm max.	10 ppm max.
N,N’-Divinyl-imidazolidone	2pp max.	2 ppm max.
Water-Soluble substance	0.5% max.	0.5% max.
Acid/Ethanol Soluble substances	1.0% max.	1.0% max.
Water	5.0% max.	5.0% max.
Particle Size	Based on Data Sheet	Based on Data Sheet

7. Safety Information

This product is generally considered non-toxic and non-irritating. In pharmaceutical applications, it has been included in the FDA's "Inactive Ingredients Guide" (for oral capsules and tablets; topical, transdermal, and vaginal preparations), and it has also been approved for use in injectable preparations in the UK. However, during use, relevant safety operating procedures should still be followed to avoid inhalation of dust or direct contact with skin and eyes. In case of accidental contact, rinse immediately with plenty of water and seek professional medical assistance.

8. Packaging and Storage

• Packaging: The standard packaging specification is a 10 kg cardboard box or a 20 kg fiber drum, both with a double layer.
• Storage: Store in a cool, ventilated, and dry area. Handle with care to prevent damage and leaks. Review the Material Safety Data Sheet (MSDS) before handling.

9. Technical Support and Services

We have a professional technical team that can provide comprehensive technical support and services. Whether it's product selection, application technical consultation, or problems encountered during production, we are committed to providing you with solutions. If you have any questions or needs regarding our Liveida® Crospovidone products, please feel free to contact our sales team or technical support staff. We will promptly answer your inquiries and provide services.